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The researchers noted, however, that success rates of these drugs are variable and the side effects can be intolerable.About products and suppliers: There's nothing quite like getting a massage after a long, stressful day. It may also stimulate the release of endothelial mediators that decrease symptoms of RLS, which include difficulty sleeping, fatigue, mood changes, and social withdrawal.Įxisting pharmacologic treatments for RLS include dopamine agonists, benzodiazepines, opioids, and anti-epileptics. Vascular compression by pneumatic compression may improve local perfusion by enhancing venous and lymphatic drainage and relieving mild and otherwise subclinical ischemia, the researchers said. They said tissue hypoxia and ischemia may lead to peripheral neuronal dysfunction. The Entre system is a basic pneumatic compression device (lymphedema pump) used to assist in the successful home management of chronic swelling and venous. Safe, effective, and noninvasive, sequential compression therapy helps prevent deep vein thrombosis (DVT) in surgical patients. However, the researchers said it may be a peripheral disorder, because chronic venous insufficiency has been shown to have a common association with RLS. In other words, it helps prevent blood clots in the legs which can happen a lot easier and quicker than people realize. The specific pathophysiology of RLS is unknown, but it is regarded to be a central nervous system disorder resulting from the dysfunction of dopaminergic and opioidergic neurotransmission mediated by the metabolism of iron. Inflation of the compression may be an effective adjunctive or alternative therapy, the researchers said.
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